Nature Communications (Nov 2017)
Quenching protein dynamics interferes with HIV capsid maturation
- Mingzhang Wang,
- Caitlin M. Quinn,
- Juan R. Perilla,
- Huilan Zhang,
- Randall Shirra Jr.,
- Guangjin Hou,
- In-Ja Byeon,
- Christopher L. Suiter,
- Sherimay Ablan,
- Emiko Urano,
- Theodore J. Nitz,
- Christopher Aiken,
- Eric O. Freed,
- Peijun Zhang,
- Klaus Schulten,
- Angela M. Gronenborn,
- Tatyana Polenova
Affiliations
- Mingzhang Wang
- Department of Chemistry and Biochemistry, University of Delaware
- Caitlin M. Quinn
- Department of Chemistry and Biochemistry, University of Delaware
- Juan R. Perilla
- Department of Chemistry and Biochemistry, University of Delaware
- Huilan Zhang
- Department of Chemistry and Biochemistry, University of Delaware
- Randall Shirra Jr.
- Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine
- Guangjin Hou
- Department of Chemistry and Biochemistry, University of Delaware
- In-Ja Byeon
- Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine
- Christopher L. Suiter
- Department of Chemistry and Biochemistry, University of Delaware
- Sherimay Ablan
- HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
- Emiko Urano
- HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
- Theodore J. Nitz
- DFH Pharma
- Christopher Aiken
- Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine
- Eric O. Freed
- HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
- Peijun Zhang
- Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine
- Klaus Schulten
- University of Illinois, Theoretical and Computational Biophysics Group
- Angela M. Gronenborn
- Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine
- Tatyana Polenova
- Department of Chemistry and Biochemistry, University of Delaware
- DOI
- https://doi.org/10.1038/s41467-017-01856-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.
