Nature Communications (Jul 2020)
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
- Kevin Litchfield,
- James L. Reading,
- Emilia L. Lim,
- Hang Xu,
- Po Liu,
- Maise Al-Bakir,
- Yien Ning Sophia Wong,
- Andrew Rowan,
- Samuel A. Funt,
- Taha Merghoub,
- David Perkins,
- Martin Lauss,
- Inge Marie Svane,
- Göran Jönsson,
- Javier Herrero,
- James Larkin,
- Sergio A. Quezada,
- Matthew D. Hellmann,
- Samra Turajlic,
- Charles Swanton
Affiliations
- Kevin Litchfield
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- James L. Reading
- Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute
- Emilia L. Lim
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- Hang Xu
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- Po Liu
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- Maise Al-Bakir
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- Yien Ning Sophia Wong
- Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute
- Andrew Rowan
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- Samuel A. Funt
- Memorial Sloan Kettering Cancer Center, Division of Solid Tumor Oncology, Department of Medicine, Weill Cornell Medical College, and Parker Center for Cancer Immunotherapy
- Taha Merghoub
- Memorial Sloan Kettering Cancer Center, Division of Solid Tumor Oncology, Department of Medicine, Weill Cornell Medical College, and Parker Center for Cancer Immunotherapy
- David Perkins
- Mass Spectrometry Proteomics, The Francis Crick Institute
- Martin Lauss
- Faculty of Medicine, Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Inge Marie Svane
- Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital Herlev
- Göran Jönsson
- Faculty of Medicine, Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University
- Javier Herrero
- Bill Lyons Informatics Centre, University College London Cancer Institute
- James Larkin
- Renal and Skin Units, The Royal Marsden Hospital
- Sergio A. Quezada
- Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute
- Matthew D. Hellmann
- Memorial Sloan Kettering Cancer Center, Division of Solid Tumor Oncology, Department of Medicine, Weill Cornell Medical College, and Parker Center for Cancer Immunotherapy
- Samra Turajlic
- Renal and Skin Units, The Royal Marsden Hospital
- Charles Swanton
- Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-020-17526-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour response to immunotherapy.
