Nature Communications (Oct 2019)
Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone
- Emily E. Noble,
- Zhuo Wang,
- Clarissa M. Liu,
- Elizabeth A. Davis,
- Andrea N. Suarez,
- Lauren M. Stein,
- Linda Tsan,
- Sarah J. Terrill,
- Ted M. Hsu,
- A-Hyun Jung,
- Lauren M. Raycraft,
- Joel D. Hahn,
- Martin Darvas,
- Alyssa M. Cortella,
- Lindsey A. Schier,
- Alexander W. Johnson,
- Matthew R. Hayes,
- Daniel P. Holschneider,
- Scott E. Kanoski
Affiliations
- Emily E. Noble
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Zhuo Wang
- Department of Psychiatry & Behavioral Sciences, University of Southern California
- Clarissa M. Liu
- Neuroscience Graduate Program, University of Southern California
- Elizabeth A. Davis
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Andrea N. Suarez
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Lauren M. Stein
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Linda Tsan
- Neuroscience Graduate Program, University of Southern California
- Sarah J. Terrill
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Ted M. Hsu
- Department of Psychology, University of Illinois at Chicago
- A-Hyun Jung
- Neuroscience Graduate Program, University of Southern California
- Lauren M. Raycraft
- Department of Psychology and Neuroscience Program, Michigan State University
- Joel D. Hahn
- Neurobiology Section, Department of Biological Sciences, University of Southern California
- Martin Darvas
- Department of Pathology, University of Washington
- Alyssa M. Cortella
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Lindsey A. Schier
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- Alexander W. Johnson
- Department of Psychology and Neuroscience Program, Michigan State University
- Matthew R. Hayes
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Daniel P. Holschneider
- Department of Psychiatry & Behavioral Sciences, University of Southern California
- Scott E. Kanoski
- Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-019-12895-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Impulsive behaviour is common in various neuropsychiatric disorders. Here, the authors identify a pathway from the lateral hypothalamus to the ventral hippocampus and the role of melanin-concentrating hormone signaling in these neurons in specifically regulating impulsivity.
