Nature Communications (Nov 2018)
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
- Bieke Decaesteker,
- Geertrui Denecker,
- Christophe Van Neste,
- Emmy M. Dolman,
- Wouter Van Loocke,
- Moritz Gartlgruber,
- Carolina Nunes,
- Fanny De Vloed,
- Pauline Depuydt,
- Karen Verboom,
- Dries Rombaut,
- Siebe Loontiens,
- Jolien De Wyn,
- Waleed M. Kholosy,
- Bianca Koopmans,
- Anke H. W. Essing,
- Carl Herrmann,
- Daniel Dreidax,
- Kaat Durinck,
- Dieter Deforce,
- Filip Van Nieuwerburgh,
- Anton Henssen,
- Rogier Versteeg,
- Valentina Boeva,
- Gudrun Schleiermacher,
- Johan van Nes,
- Pieter Mestdagh,
- Suzanne Vanhauwaert,
- Johannes H. Schulte,
- Frank Westermann,
- Jan J. Molenaar,
- Katleen De Preter,
- Frank Speleman
Affiliations
- Bieke Decaesteker
- Center for Medical Genetics, Ghent University
- Geertrui Denecker
- Center for Medical Genetics, Ghent University
- Christophe Van Neste
- Center for Medical Genetics, Ghent University
- Emmy M. Dolman
- Princess Máxima Center for Pediatric Oncology, Department of Translational Research
- Wouter Van Loocke
- Center for Medical Genetics, Ghent University
- Moritz Gartlgruber
- Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Carolina Nunes
- Center for Medical Genetics, Ghent University
- Fanny De Vloed
- Center for Medical Genetics, Ghent University
- Pauline Depuydt
- Center for Medical Genetics, Ghent University
- Karen Verboom
- Center for Medical Genetics, Ghent University
- Dries Rombaut
- Center for Medical Genetics, Ghent University
- Siebe Loontiens
- Center for Medical Genetics, Ghent University
- Jolien De Wyn
- Center for Medical Genetics, Ghent University
- Waleed M. Kholosy
- Princess Máxima Center for Pediatric Oncology, Department of Translational Research
- Bianca Koopmans
- Princess Máxima Center for Pediatric Oncology, Department of Translational Research
- Anke H. W. Essing
- Princess Máxima Center for Pediatric Oncology, Department of Translational Research
- Carl Herrmann
- Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg
- Daniel Dreidax
- Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Kaat Durinck
- Center for Medical Genetics, Ghent University
- Dieter Deforce
- Cancer Research Institute Ghent (CRIG)
- Filip Van Nieuwerburgh
- Cancer Research Institute Ghent (CRIG)
- Anton Henssen
- Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin
- Rogier Versteeg
- Department of Oncogenomics, Academic Medical Center
- Valentina Boeva
- Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris Descartes University UMR-S1016
- Gudrun Schleiermacher
- Institut Curie, PSL Research University, Equipe Labellisée Ligue contre le Cancer, Laboratory Recherche Translationnelle en Oncologie Pédiatrique (RTOP), Laboratoire “Gilles Thomas”, Institut Curie, Department of Translational Research, Institut Curie, SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie
- Johan van Nes
- Department of Oncogenomics, Academic Medical Center
- Pieter Mestdagh
- Center for Medical Genetics, Ghent University
- Suzanne Vanhauwaert
- Center for Medical Genetics, Ghent University
- Johannes H. Schulte
- Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin
- Frank Westermann
- Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Jan J. Molenaar
- Princess Máxima Center for Pediatric Oncology, Department of Translational Research
- Katleen De Preter
- Center for Medical Genetics, Ghent University
- Frank Speleman
- Center for Medical Genetics, Ghent University
- DOI
- https://doi.org/10.1038/s41467-018-06699-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM targets by MYCN/FOXM1.
