مجله دانشکده پزشکی اصفهان (Sep 2014)
Clinical Studies Regarding Relation of Insulin Resistant Syndrome and Colorectal Polyps in People with 50 Years of Age and More
Abstract
Background: Insulin resistance is a condition in the form of the lack of sensitivity of the tissues for removing glucose. Colorectal polyps, with the histology basis, have the risk in transforming to the malignant neoplastic form. There are some uncontrollable risk-factors that influence the immergence colorectal neoplasms; though some of them are relatively controllable, among which the insulin resistance could be named. The aim of this investigation was analyzing the relation between insulin resistance and affecting to colorectal neoplasms in the people with 50 years of age or more. Methods: This descriptive-analytic cross-sectional study was conducted on 200 patients with 50 years of age and more, with indications of colonoscopy and without the risk factors such as family history of colon cancer cancer, intestinal inflammation, anemia, rectal bleeding and so on. Blood pressure, waist circumference, height and weight of patients were measured. The levels of high-density lipoprotein (HDL), fasting blood sugar (FBS), triglyceride (TG), and plasma insulin were measured and then, they underwent colonoscopy. In case of observing any abnormal disorders, the samples were sent for pathological controls. Finally, the recorded data were analyzed. Findings: The frequency of colorectal polyps were more in patients with insulin resistance syndrome (P = 0.007). There were significant relations between people with insulin resistance syndrome, the people with raised fasting blood sugar, and the ladies with low HDL and metabolic syndrome with the adenoma with advanced pathology (P 0.05). Conclusion: This study shows that the frequency of colorectal polyps, especially with the advanced pathology, is more in the people with insulin resistance or diabetes mellitus or the people who are susceptible to diabetes. It is recommended for the mentioned patients to have investigations of colonoscopy in younger ages to prevent deaths due to colorectal cancer. It is also necessary to have more investigations in this regard.
