Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males

Debashish U. Menon; Oleksandr Kirsanov; Christopher B. Geyer; Terry Magnuson

doi:10.1038/s41467-021-26828-1

Nature Communications (Nov 2021)

Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males

Debashish U. Menon,
Oleksandr Kirsanov,
Christopher B. Geyer,
Terry Magnuson

Affiliations

Debashish U. Menon: Department of Genetics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
Oleksandr Kirsanov: Department of Anatomy & Cell Biology at the Brody School of Medicine, East Carolina University
Christopher B. Geyer: Department of Anatomy & Cell Biology at the Brody School of Medicine, East Carolina University
Terry Magnuson: Department of Genetics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-021-26828-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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The mammalian SWI/SNF nucleosome remodeler is required for spermatogenesis. Here, the authors show that PBAF is essential for meiotic cell division in males and required to activate the expression of critical genes involved in spindle assembly and nuclear division in spermatocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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