The Role of Urine F2-isoprostane Concentration in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Haemorrhage—A Poor Prognostic Factor

Karol Wiśniewski; Marta Popęda; Bartłomiej Tomasik; Michał Bieńkowski; Ernest J. Bobeff; Ludomir Stefańczyk; Krzysztof Tybor; Marlena Hupało; Dariusz J. Jaskólski

doi:10.3390/diagnostics11010005

Diagnostics (Dec 2020)

The Role of Urine F2-isoprostane Concentration in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Haemorrhage—A Poor Prognostic Factor

Karol Wiśniewski,
Marta Popęda,
Bartłomiej Tomasik,
Michał Bieńkowski,
Ernest J. Bobeff,
Ludomir Stefańczyk,
Krzysztof Tybor,
Marlena Hupało,
Dariusz J. Jaskólski

Affiliations

Karol Wiśniewski: Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland
Marta Popęda: Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland
Bartłomiej Tomasik: Department of Biostatistics and Translational Medicine, Medical University of Lodz, 15 Mazowiecka St., 92-215 Lodz, Poland
Michał Bieńkowski: Department of Pathomorphology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland
Ernest J. Bobeff: Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland
Ludomir Stefańczyk: Department of Radiology—Diagnostic Imaging, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland
Krzysztof Tybor: Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland
Marlena Hupało: Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland
Dariusz J. Jaskólski: Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland

DOI: https://doi.org/10.3390/diagnostics11010005
Journal volume & issue: Vol. 11, no. 1
p. 5

Abstract

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Background: The pathophysiology of delayed cerebral ischemia (DCI) remains unclear. One of the hypotheses suggests that reactive oxygen species play a role in its onset. Thus, we studied F2-isoprostanes (F2-IsoPs)—oxidative stress biomarkers. Our goal was to improve the early diagnosis of DCI in a non-invasive way. Methods: We conducted a prospective single center analysis of 38 aneurysmal subarachnoid hemorrhage patients. We assessed urine F2-IsoP concentration using immunoenzymatic arrays between the first and fifth day after bleeding. A correlation between urine F2-IsoP concentration and DCI occurrence was examined regarding clinical conditions and outcomes. Results: The urine F2-IsoP concentrations were greater than those in the control groups (p p p Conclusions: High levels of urine F2-IsoPs on day 3 can herald DCI.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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