Biomedicines (Dec 2022)

Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research

  • Jia-Jung Lee,
  • Chuang-Yu Lin,
  • Hung-Chun Chen,
  • Patrick C. H. Hsieh,
  • Yi-Wen Chiu,
  • Jer-Ming Chang

DOI
https://doi.org/10.3390/biomedicines10123232
Journal volume & issue
Vol. 10, no. 12
p. 3232

Abstract

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Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and characterization technologies since then has supported their applications from disease modeling and preclinical experimental platforms to the initiation of cell therapies. In this review, we started with a background introduction about stem cells and the discovery of iPSCs, examined the developing technologies in reprogramming and characterization, and provided the updated list of stem cell biobanks. We highlighted several important iPSC-based research including that on autosomal dominant kidney disease and SARS-CoV-2 kidney involvement and discussed challenges and future perspectives.

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