Mast Cells and Arachidonic Acid Cascade in Inflammation

M.L. Castellani; M. Felaco; F. Pandolfi; V. Salini; D. De Amicis; C. Orso; J. Vecchiet; S. Tetè; C. Ciampoli; F. Conti; G. Cerulli; A. Caraffa; P. Antinolfi; C. Cuccurullo; P. Felaco; D. Kempuraj; P. Boscolo; G. Sabatino; Y.B. Shaik

doi:10.1177/1721727X0900700302

European Journal of Inflammation (Sep 2009)

Mast Cells and Arachidonic Acid Cascade in Inflammation

M.L. Castellani,
M. Felaco,
F. Pandolfi,
V. Salini,
D. De Amicis,
C. Orso,
J. Vecchiet,
S. Tetè,
C. Ciampoli,
F. Conti,
G. Cerulli,
A. Caraffa,
P. Antinolfi,
C. Cuccurullo,
P. Felaco,
D. Kempuraj,
P. Boscolo,
G. Sabatino,
Y.B. Shaik

Affiliations

M.L. Castellani: Immunology Division, Medical School, University of Chieti-Pescara, Italy
M. Felaco: Division of Biology, University of Chieti, Italy
F. Pandolfi: Catholic University, Rome, Italy
V. Salini: Department of Human Dynamics, University of Chieti-Pescara, Italy
D. De Amicis: Department of Human Dynamics, University of Chieti-Pescara, Italy
C. Orso: Department of Human Dynamics, University of Chieti-Pescara, Italy
J. Vecchiet: Clinic of Infectious Diseases, Medical School, University of Chieti-Pescara, Italy
S. Tetè: Dental School, University of Chieti-Pescara, Italy
C. Ciampoli: Dental School, University of Chieti-Pescara, Italy
F. Conti: Gynecology Division, University of Chieti, Italy
G. Cerulli: Orthopeadics Division, University of Perugia, Italy
A. Caraffa: Orthopeadics Division, University of Perugia, Italy
P. Antinolfi: Orthopeadics Division, University of Perugia, Italy
C. Cuccurullo: Division of Medical Pathology, University of Chieti
P. Felaco: Nephrology Division, University of Chieti, Chieti, Italy
D. Kempuraj: Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA, USA
P. Boscolo: Department of Biomedical Science, University of Chieti, Chieti, Italy
G. Sabatino: Department of Paediatrics, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy
Y.B. Shaik: Department of Medicine, Boston University School of Medicine, Boston, MA, USA

DOI: https://doi.org/10.1177/1721727X0900700302
Journal volume & issue: Vol. 7

Abstract

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Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in diseases, such as allergic diseases. PGD2 may act as a neuromodulator and as an allergic and inflammatory mediator. In allergic diseases, activated mast cell synthesizes prostaglandin D2 (first cyclo-oxygenate mediator) which has bronchoconstrictive and vasodilating effects and attracts several leukocytes. It has been found that activated mast cells, challenged with physiological and non- physiological secretagogues, release elevated histamine and tryptase and chymase, leukotrienes B4, C4 and D4, 5-hydroxyeicosatetraenoic acid, PGD2, Platelet Activating Factor (PAF), heparin, and high-molecular-weight neutrophil chemotactic factor and cytokines/chemokines. PGD2 exerts its biological activity through the DP and CRTH2 receptors and their cDNA cloning which were characterized 15 years ago. In this report, we revisited the biological effects of arachidonic acid compounds released by activated mast cells in allergic and inflammatory states.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

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