Parietal Fast Sleep Spindle Density Decrease in Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

Maurizio Gorgoni; Giulia Lauri; Ilaria Truglia; Susanna Cordone; Simone Sarasso; Serena Scarpelli; Anastasia Mangiaruga; Aurora D’Atri; Daniela Tempesta; Michele Ferrara; Camillo Marra; Paolo Maria Rossini; Luigi De Gennaro

doi:10.1155/2016/8376108

Neural Plasticity (Jan 2016)

Parietal Fast Sleep Spindle Density Decrease in Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

Maurizio Gorgoni,
Giulia Lauri,
Ilaria Truglia,
Susanna Cordone,
Simone Sarasso,
Serena Scarpelli,
Anastasia Mangiaruga,
Aurora D’Atri,
Daniela Tempesta,
Michele Ferrara,
Camillo Marra,
Paolo Maria Rossini,
Luigi De Gennaro

Affiliations

Maurizio Gorgoni: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Giulia Lauri: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Ilaria Truglia: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Susanna Cordone: Department of Physiology and Pharmacology, “Sapienza” University of Rome, 00185 Rome, Italy
Simone Sarasso: Department of Biomedical and Clinical Sciences “Luigi Sacco”, University of Milan, 20157 Milan, Italy
Serena Scarpelli: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Anastasia Mangiaruga: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Aurora D’Atri: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy
Daniela Tempesta: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Michele Ferrara: Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 Coppito, Italy
Camillo Marra: Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy
Paolo Maria Rossini: Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy
Luigi De Gennaro: Department of Psychology, “Sapienza” University of Rome, 00185 Rome, Italy

DOI: https://doi.org/10.1155/2016/8376108
Journal volume & issue: Vol. 2016

Abstract

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Several studies have identified two types of sleep spindles: fast (13–15 Hz) centroparietal and slow (11–13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development.

Published in Neural Plasticity

ISSN: 2090-5904 (Print); 1687-5443 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://onlinelibrary.wiley.com/journal/6020

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