Nature Communications (Jun 2018)
Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
- Jiejie Wang,
- Xinyou Lv,
- Yu Wu,
- Tao Xu,
- Mingfei Jiao,
- Risheng Yang,
- Xia Li,
- Ming Chen,
- Yinggang Yan,
- Changwan Chen,
- Weifan Dong,
- Wei Yang,
- Min Zhuo,
- Tao Chen,
- Jianhong Luo,
- Shuang Qiu
Affiliations
- Jiejie Wang
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Xinyou Lv
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Yu Wu
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Tao Xu
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Mingfei Jiao
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Risheng Yang
- Department of Anatomy, Histology and Embryology, Fourth Military Medical University
- Xia Li
- Department of Anatomy, Histology and Embryology, Fourth Military Medical University
- Ming Chen
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Yinggang Yan
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Changwan Chen
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Weifan Dong
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Wei Yang
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Min Zhuo
- Center for Neuron and Disease, Frontier Institutes of Life Science, Science and Technology, Xi’an Jiaotong University
- Tao Chen
- Department of Anatomy, Histology and Embryology, Fourth Military Medical University
- Jianhong Luo
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- Shuang Qiu
- Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou
- DOI
- https://doi.org/10.1038/s41467-018-04672-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response.
