Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in the Survival of Patients with Esophageal Cancer

Abstract

Background: Different factors can affect the future of a person with cancer. Patient’s systemic inflammatory response is an important factor. Several inflammatory markers have been evaluated for measuring the patient’s response to cancer. In this retrospective cohort study, we evaluated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as prognostic factors of surveillance in patients with pathologic approved esophageal cancer. Methods: In this retrospective cohort study, patients with pathologically approved esophageal cancer, who underwent surgical treatment in cancer institute of Iran, were included. Demographic, pathologic and laboratory data of patients were obtained from archive of medical records. Results: In this study 135 patients with esophageal cancer with mean age of 60 years were studied.The median time of follow-up period was 21 months. Mean NLR and PLR were 7.05 and 898 respectively. Patients’ survival had a significant relationship with patients’ age, gender, tumor’s diffrentiation, receiving chemotherapy, absolute neutrophil count, total bilirubin, direct bilirubin, and NLR. Conclusion: According to the results, in a multi variable investigation, it was demonstrated that a high NLR has a direct effect on patients’ poor survival.

Keywords

• esophageal cancer
• survival
• neutrophils
• lymphocytes
• platelets
• surgery