Aktualʹnaâ Infektologiâ (Oct 2019)
Evaluation of the effectiveness of the treatment of intestinal ascariasis in children
Abstract
Background. Parasitic diseases remain one of the most common types of pathology in the XXI century and are a medical and social problem. Of the identified helminths, 90 % of cases occur in the pediatric population. Ascariasis and enterobiasis are the most common. A comprehensive approach to the correction of disorders caused by both the use of anthelmintic drugs and the presence of helminths in the body. The purpose was to evaluate the effectiveness of complex treatment of intestinal ascariasis in children. Materials and methods. The work is based on the results of a survey of 178 children aged 3 to 18 years with intestinal form of ascariasis. Ascariasis was diagnosed using coprological survey and the Parasep concentration method. The examined children were divided into two groups: group I (n = 99) received albendazole (200–400 mg per day) in the complex treatment of ascariasis (antihistamine, sorbent, probiotic); group II (n = 80) received Vormil Fito in addition to the standard scheme. Results. The average duration of pain relief in children was 3.6 ± 0.2 and 2.6 ± 0.9 days in comparison group and in the basic group, respectively, p < 0.001. The dyspeptic syndrome signs were reduced within 5.3 ± 0.3 and 4.3 ± 0.2 days in the comparison group and in the basic group, respectively, p < 0.01. The signs of asthenovegetative syndrome in children of the comparison group were eliminated within 8–10 days, while for the children of the basic group — within 6–7 days. The use of complex treatment of children allowed reducing the time of pain relief by 27.8 %, dyspeptic and asthenovegetative syndromes by 14.0 and 25.0 %, respectively. Clinical recovery in children treated with the proposed method was faster, on average by 1.8 times, compared to the treatment with abendazole (Vormil) only. The parasitological efficacy of the proposed method is 95 %, whereas the use of albendazole (Vormil) alone is 89.8 %. Conclusions. Adding the phytocomplex of Vormil Fito to the scheme of treatment of patients with ascariasis accelerates the recovery of patients, quickly improves their wellbeing, provides high clinical and antiparasitic efficacy.
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