STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Hongxu Xian; Qiaoyun Yang; Lin Xiao; Han-Ming Shen; Yih-Cherng Liou

doi:10.1038/s41467-019-10096-1

Nature Communications (May 2019)

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Hongxu Xian,
Qiaoyun Yang,
Lin Xiao,
Han-Ming Shen,
Yih-Cherng Liou

Affiliations

Hongxu Xian: Department of Biological Sciences, Faculty of Science, National University of Singapore
Qiaoyun Yang: Department of Biological Sciences, Faculty of Science, National University of Singapore
Lin Xiao: Department of Biological Sciences, Faculty of Science, National University of Singapore
Han-Ming Shen: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Yih-Cherng Liou: Department of Biological Sciences, Faculty of Science, National University of Singapore

DOI: https://doi.org/10.1038/s41467-019-10096-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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