Evaluation of Serum Serotonin as a Biomarker for Myocardial Infarction and Ischemia/Reperfusion Injury

Marina Rieder; Rosmarie Laumann; Thilo Witsch; Nancy Schanze; Lukas Heger; Christoph B. Olivier; Constantin von zur Muehlen; Christoph Bode; Ingo Ahrens; Achim Lother; Daniel Duerschmied; Marcus Hortmann

doi:10.3390/app10186379

Applied Sciences (Sep 2020)

Evaluation of Serum Serotonin as a Biomarker for Myocardial Infarction and Ischemia/Reperfusion Injury

Marina Rieder,
Rosmarie Laumann,
Thilo Witsch,
Nancy Schanze,
Lukas Heger,
Christoph B. Olivier,
Constantin von zur Muehlen,
Christoph Bode,
Ingo Ahrens,
Achim Lother,
Daniel Duerschmied,
Marcus Hortmann

Affiliations

Marina Rieder: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Rosmarie Laumann: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Thilo Witsch: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Nancy Schanze: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Lukas Heger: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Christoph B. Olivier: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Constantin von zur Muehlen: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Christoph Bode: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Ingo Ahrens: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Achim Lother: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Daniel Duerschmied: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany
Marcus Hortmann: Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, Germany

DOI: https://doi.org/10.3390/app10186379
Journal volume & issue: Vol. 10, no. 18
p. 6379

Abstract

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Background: Activated platelets release serotonin during acute myocardial infarction (AMI), aggravating myocardial damage and ischemia/reperfusion (I/R) injury. However, serum serotonin and its potential role as a biomarker for myocardial infarction and I/R injury have not been studied so far. Methods: In this investigator-initiated pilot study, we examined 38 patients with ST-segment myocardial infarction (STEMI). We determined serum serotonin levels prior to percutaneous coronary intervention and 8, 16, and 24 h afterwards. We studied whether serum serotonin was associated with I/R injury assessed by ECG analysis and by analysis of TIMI myocardial perfusion grade (TMP) and myocardial blush grade (MGB). Serum serotonin levels were compared to an age-matched control group consisting of patients admitted to the emergency department for any other reason than STEMI. Results: Serum serotonin levels were not elevated in the myocardial infarction group compared to the control cohort and they did not show any timeline kinetics after STEMI. They were not associated with the severity of coronary artery disease, the outcome of coronary angiography, the extent of I/R injury, or the degree of heart failure. Conclusions: Serum serotonin is not suitable as a biomarker after myocardial infarction and in the assessment of I/R injury.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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