Clinical Efficacy of Ozone Therapy in Peri-implant Diseases: A Systematic Review

Abstract

Introduction: With an increasing number of dental implants being placed each year, there has been a consequent rise in the frequency of peri-implant diseases. Ozone, a potent antibacterial agent, eliminates the microbes that cause infections around implants. Aim: To assess ozone therapy’s effectiveness of ozone therapy as an adjunct in the treatment of peri-implant diseases. Materials and Methods: A complete search was conducted in electronic databases such as PubMed, Google Scholar, and Cochrane, employing the eligibility criteria. After a thorough review, six studies published from 2013 to 2023 that evaluated the effectiveness of ozone therapy in clinical trials for the management of peri-implant diseases were included in this systematic review. Results: The six selected studies evaluated ozone therapy as a treatment for peri-implant diseases and evaluated relevant clinical indices. Four studies were in-vivo, out of which one evaluated peri-implantitis and three on peri-implant mucositis. Three studies showed a reduction in the Plaque Index (PI) during follow-up, while one study stated that it showed improvement at one month, with no significant further reduction seen. Two in-vitro studies stated that ozone therapy helped reduce bacterial adherence to the implant surface. Conclusion: Considering the findings of the previous studies, the present systematic review concludes that ozone therapy shows progressive improvement in the management of peri-implant diseases.

Keywords

• dental implants
• peri-implantitis
• peri-implant mucositis
• oxygen therapy