Unusual ocular Hodgkinʼs-like lymphoma in a dog

Abstract

Hodgkin’s disease is a malignant lymphoproliferative disease with various gross morphology. The present paper reports gross and microscopic features of Hodgkinʼs-like lymphoma in a dog. An eight years-old dog was presented to our hospital due to complete blindness associated with the presence of proliferative tissue on the globe surface. The tissue biopsy sample was soft and frigid with high bleeding tendency and was processed for histopathological evaluation. Sections of 5 μm in thickness were stained with haematoxylin-eosin and melan-A and S-100 by immunohistochemistry (IHC) for differential diagnosis with ocular melanoma. Histologically, regarding the negative Melan-A and S100 IHC findings, and particular histological features, a mixed cellularity type of Hodgkin’s disease which included a large number of lymphocytes with different size and shape together with single necrosis was diagnosed. Additionally, Reed-Sternberg cells which had a deeply lobulated nucleus were demonstrated.

Keywords

• dog
• histopathology
• hodgkin’s disease
• reed-sternberg cell