The genotypic antibiogram: using gram-negative antimicrobial resistance genes identified via rapid blood culture identification tests to optimize treatment of Enterobacterales bloodstream infections

Shawnalyn W. Sunagawa; Jeremy Tigh; Yolande A. Chan; Ashlyn Okada; Scott J. Bergman; Trevor C. Van Schooneveld; Paul D. Fey; Jonathan H. Ryder

doi:10.1017/ash.2024.406

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2024)

The genotypic antibiogram: using gram-negative antimicrobial resistance genes identified via rapid blood culture identification tests to optimize treatment of Enterobacterales bloodstream infections

Shawnalyn W. Sunagawa,
Jeremy Tigh,
Yolande A. Chan,
Ashlyn Okada,
Scott J. Bergman,
Trevor C. Van Schooneveld,
Paul D. Fey,
Jonathan H. Ryder

Affiliations

Shawnalyn W. Sunagawa: ORCiD; Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE, USA College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
Jeremy Tigh: Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE, USA
Yolande A. Chan: Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA
Ashlyn Okada: Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE, USA
Scott J. Bergman: ORCiD; Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE, USA College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
Trevor C. Van Schooneveld: ORCiD; Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA
Paul D. Fey: Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA
Jonathan H. Ryder: ORCiD; Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA

DOI: https://doi.org/10.1017/ash.2024.406
Journal volume & issue: Vol. 4

Abstract

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The negative predictive value of bla CTX-M on BCID2 for ceftriaxone resistance in E. coli and K. pneumoniae group was 97% and 94%, respectively. Creation of a genotypic antibiogram led to updated local guidance for clinicians to utilize for empiric treatment of Enterobacterales bloodstream infections identified via rapid diagnostics.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

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