Nature Communications (Jan 2023)

The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase

  • Jiyao Song,
  • Liesa Steidle,
  • Isabelle Steymans,
  • Jasjot Singh,
  • Anne Sanner,
  • Lena Böttinger,
  • Dominic Winter,
  • Thomas Becker

DOI
https://doi.org/10.1038/s41467-022-35720-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.