Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE

Weiguang Wang; Kirill Tsirulnikov; Hristina R. Zhekova; Gülru Kayık; Hanif Muhammad Khan; Rustam Azimov; Natalia Abuladze; Liyo Kao; Debbie Newman; Sergei Yu. Noskov; Z. Hong Zhou; Alexander Pushkin; Ira Kurtz

doi:10.1038/s41467-021-25998-2

Nature Communications (Sep 2021)

Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE

Weiguang Wang,
Kirill Tsirulnikov,
Hristina R. Zhekova,
Gülru Kayık,
Hanif Muhammad Khan,
Rustam Azimov,
Natalia Abuladze,
Liyo Kao,
Debbie Newman,
Sergei Yu. Noskov,
Z. Hong Zhou,
Alexander Pushkin,
Ira Kurtz

Affiliations

Weiguang Wang: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Kirill Tsirulnikov: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Hristina R. Zhekova: Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
Gülru Kayık: Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
Hanif Muhammad Khan: Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
Rustam Azimov: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Natalia Abuladze: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Liyo Kao: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Debbie Newman: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Sergei Yu. Noskov: Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary
Z. Hong Zhou: Electron Imaging Center for Nanomachines, California NanoSystems Institute, University of California
Alexander Pushkin: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California
Ira Kurtz: Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California

DOI: https://doi.org/10.1038/s41467-021-25998-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The mechanisms involved in SLC4-mediated ion transport are still under debate. Here, the authors present a cryoEM structure of the Sodium-driven Chloride/Bicarbonate Exchanger NDCBE, which - together with computational modeling and mutagenesis - reveals molecular determinants of ion transport by SLC4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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