Nature Communications (Jan 2023)
Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity
- Jing Lin,
- Shihui Sun,
- Kui Zhao,
- Fei Gao,
- Renling Wang,
- Qi Li,
- Yanlong Zhou,
- Jing Zhang,
- Yue Li,
- Xinyue Wang,
- Le Du,
- Shuai Wang,
- Zi Li,
- Huijun Lu,
- Yungang Lan,
- Deguang Song,
- Wei Guo,
- Yujia Chen,
- Feng Gao,
- Yicheng Zhao,
- Rongrong Fan,
- Jiyu Guan,
- Wenqi He
Affiliations
- Jing Lin
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Shihui Sun
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Kui Zhao
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Fei Gao
- Department of Laboratory Animals, College of Animal Science, Jilin University
- Renling Wang
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Qi Li
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Yanlong Zhou
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Jing Zhang
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Yue Li
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Xinyue Wang
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Le Du
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Shuai Wang
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Zi Li
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Huijun Lu
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Yungang Lan
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Deguang Song
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Wei Guo
- Department of Hematology, The first hospital of Jilin University
- Yujia Chen
- Department of Gastrointestinal Surgery, The first hospital of Jilin University
- Feng Gao
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Yicheng Zhao
- Changchun University of Chinese Medicine
- Rongrong Fan
- Department of Biosciences and Nutrition, Karolinska Institutet
- Jiyu Guan
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- Wenqi He
- Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University
- DOI
- https://doi.org/10.1038/s41467-023-35917-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell death mechanism, is the dominant cell death pathway during virotherapy.
