Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones

Abstract

We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols.

Keywords

• 1,3-amino alcohols
• 3-aminocyclohexanols
• β-enaminoketones
• reduction of β-enaminoketones