Ocular involvement in a case of dystrophic epidermolysis bullosa with conjunctival blistering without eyelid or corneal disease: A rare case report

Abstract

Epidermolysis bullosa (EB) is an autoimmune mucocutaneous disorder associated with abnormalities of the basement membrane zone of skin and mucous membranes, characterized by blister formation in response to minor trauma. Ocular involvement is common in autosomal dominant variant of dystrophic EB (DDEB), but the incidence of involvement of ocular structures varies widely among different patients as well as among different subtypes. Conjunctival blistering without eyelid or corneal disease is one of the most common ocular manifestations. Here, we present a rare case of DDEB in a 4-year-old boy with conjunctival blister formation without eyelid or corneal involvement. The patient was managed conservatively with lubricating eye drops, and the conjunctival blister resolved subsequently. The major treatment modality is the use of ocular lubricants. Protection of eye from minor trauma such as rubbing is most important to prevent ocular complications.

Keywords

• autoimmune
• blistering skin lesions
• conjunctival blister
• dystrophic epidermolysis bullosa
• mucocutaneous