Nature Communications (Feb 2019)
Outcomes of controlled human malaria infection after BCG vaccination
- Jona Walk,
- L. Charlotte J. de Bree,
- Wouter Graumans,
- Rianne Stoter,
- Geert-Jan van Gemert,
- Marga van de Vegte-Bolmer,
- Karina Teelen,
- Cornelus C. Hermsen,
- Rob J. W. Arts,
- Marije C. Behet,
- Farid Keramati,
- Simone J. C. F. M. Moorlag,
- Annie S. P. Yang,
- Reinout van Crevel,
- Peter Aaby,
- Quirijn de Mast,
- André J. A. M. van der Ven,
- Christine Stabell Benn,
- Mihai G. Netea,
- Robert W. Sauerwein
Affiliations
- Jona Walk
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- L. Charlotte J. de Bree
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Wouter Graumans
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Rianne Stoter
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Geert-Jan van Gemert
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Marga van de Vegte-Bolmer
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Karina Teelen
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Cornelus C. Hermsen
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Rob J. W. Arts
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Marije C. Behet
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Farid Keramati
- Department of Molecular Biology, Faculty of Science, Radboud university
- Simone J. C. F. M. Moorlag
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Annie S. P. Yang
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- Reinout van Crevel
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Peter Aaby
- Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut
- Quirijn de Mast
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- André J. A. M. van der Ven
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Christine Stabell Benn
- Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut
- Mihai G. Netea
- Radboud Center for Infectious Diseases, Radboud University Medical Center PO Box 9101
- Robert W. Sauerwein
- Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101
- DOI
- https://doi.org/10.1038/s41467-019-08659-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 8
Abstract
Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.
