Nature Communications (Jan 2020)
Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
- Ke Zhu,
- Yumei Lai,
- Huiling Cao,
- Xiaochun Bai,
- Chuanju Liu,
- Qinnan Yan,
- Liting Ma,
- Di Chen,
- Giedrius Kanaporis,
- Junqi Wang,
- Luyuan Li,
- Tao Cheng,
- Yong Wang,
- Chuanyue Wu,
- Guozhi Xiao
Affiliations
- Ke Zhu
- Department of Orthopedic Surgery, Rush University Medical Center
- Yumei Lai
- Department of Orthopedic Surgery, Rush University Medical Center
- Huiling Cao
- Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and Technology
- Xiaochun Bai
- Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Chuanju Liu
- Department of Orthopedic Surgery, New York University School of Medicine
- Qinnan Yan
- Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and Technology
- Liting Ma
- Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and Technology
- Di Chen
- Department of Orthopedic Surgery, Rush University Medical Center
- Giedrius Kanaporis
- Department of Molecular Biophysics and Physiology, Rush University Medical Center
- Junqi Wang
- Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and Technology
- Luyuan Li
- State Key Laboratory of Medicinal Chemical Biology and Nankai University College of Pharmacy
- Tao Cheng
- State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College
- Yong Wang
- UVA Islet Microfluidic Laboratory, Department of Surgery, the University of Virginia
- Chuanyue Wu
- Department of Pathology, University of Pittsburgh
- Guozhi Xiao
- Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-14186-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.
