Nature Communications (Jan 2021)

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

  • Catherine A. Vaughan,
  • Shilpa Singh,
  • Mark A. Subler,
  • Jolene J. Windle,
  • Kazushi Inoue,
  • Elizabeth A. Fry,
  • Raghavendra Pillappa,
  • Steven R. Grossman,
  • Brad Windle,
  • W. Andrew Yeudall,
  • Swati Palit Deb,
  • Sumitra Deb

DOI
https://doi.org/10.1038/s41467-021-20928-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of GOF mutant p53.