Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points

Amin Mahpour; Alan C. Mullen

JHEP Reports (Feb 2021)

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancyKey points

Amin Mahpour,
Alan C. Mullen

Affiliations

Amin Mahpour: Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA
Alan C. Mullen: Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Corresponding author. Address: Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Journal volume & issue: Vol. 3, no. 1
p. 100177

Abstract

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Summary: Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.

Published in JHEP Reports

ISSN: 2589-5559 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.journals.elsevier.com/jhep-reports

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Abstract

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