Multi-omic data integration enables discovery of hidden biological regularities

Ali Ebrahim; Elizabeth Brunk; Justin Tan; Edward J. O'Brien; Donghyuk Kim; Richard Szubin; Joshua A. Lerman; Anna Lechner; Anand Sastry; Aarash Bordbar; Adam M. Feist; Bernhard O. Palsson

doi:10.1038/ncomms13091

Nature Communications (Oct 2016)

Multi-omic data integration enables discovery of hidden biological regularities

Ali Ebrahim,
Elizabeth Brunk,
Justin Tan,
Edward J. O'Brien,
Donghyuk Kim,
Richard Szubin,
Joshua A. Lerman,
Anna Lechner,
Anand Sastry,
Aarash Bordbar,
Adam M. Feist,
Bernhard O. Palsson

Affiliations

Ali Ebrahim: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Elizabeth Brunk: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Justin Tan: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Edward J. O'Brien: Bioinformatics and Systems Biology Program, University of California
Donghyuk Kim: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Richard Szubin: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Joshua A. Lerman: Bioinformatics and Systems Biology Program, University of California
Anna Lechner: Department of Chemical and Biomolecular Engineering, University of California
Anand Sastry: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Aarash Bordbar: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Adam M. Feist: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA
Bernhard O. Palsson: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, California 92093, USA

DOI: https://doi.org/10.1038/ncomms13091
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Translating omics data sets into biological insight is one of the great challenges of our time. Here, the authors make headway by synchronising pairs of omics data types via invariants across conditions and by integrating datasets into a genome-scale model of E. coli metabolism and gene expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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