Communications Biology (Jun 2021)
Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
- Takuto Hayashi,
- Takashi Kudo,
- Ryo Fujita,
- Shin-ichiro Fujita,
- Hirona Tsubouchi,
- Sayaka Fuseya,
- Riku Suzuki,
- Michito Hamada,
- Risa Okada,
- Masafumi Muratani,
- Dai Shiba,
- Takafumi Suzuki,
- Eiji Warabi,
- Masayuki Yamamoto,
- Satoru Takahashi
Affiliations
- Takuto Hayashi
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Takashi Kudo
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Ryo Fujita
- Divsion of Regenerative Medicine, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba
- Shin-ichiro Fujita
- Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
- Hirona Tsubouchi
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Sayaka Fuseya
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Riku Suzuki
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Michito Hamada
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Risa Okada
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Masafumi Muratani
- Department of Genome Biology, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba
- Dai Shiba
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Takafumi Suzuki
- Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
- Eiji Warabi
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Masayuki Yamamoto
- Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
- Satoru Takahashi
- Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- DOI
- https://doi.org/10.1038/s42003-021-02334-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 12
Abstract
Hayashi et al. report on the effect of space flight on muscle mass, fibre size and type, composition and gene signalling of muscle in WT and Nrf2-KO mice. Their results demonstrate a key role of NRF2 in maintaining the slow-type fibres of soleus muscle during space flight and in microgravity environments.
