Nature Communications (Aug 2019)

Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

  • Alexandra Tzilivaki,
  • George Kastellakis,
  • Panayiota Poirazi

DOI
https://doi.org/10.1038/s41467-019-11537-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Recent experimental work has revealed non-linear dendritic integration in interneurons. Here, the authors show, through detailed biophysical modeling, that fast spiking interneurons are better described with a 2-stage artificial neural network model calling into question the use of point neuron models.