P96 ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENTS WITH ARTERIAL STIFFNESS IN GENERAL POPULATION OF THE EVA STUDY

Abstract

Objective: The aim of this study is to investigate the relationship of Metabolic Syndrome (MetS) and its components with arterial stiffness in general population without cardiovascular diseases. Design and method: Cross-sectional study of general population without cardiovascular diseases. There were included 500 subjects between 35–75 years old, selected by random sampling with replacement, stratified by age and gender groups using the Sanitary Card base of 5 urban health centers. Measurements: Pulse wave velocity femoral carotid (cfPWV) was determined using the SphygmoCor System, Cardio Ankle Vascular Index (CAVI) using the VaSera. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Results: Mean age was 55.9 ± 14.2years, mean cfPWV was 6.5 ± 2.0 m/sec and mean CAVI was:8.0 ± 1.4. MetS was found in 14% of the subjects. cfPWV and CAVI were higher in subjects with MetS. All MetS components, except reduced HDL-cholesterol, were correlated with cfPWV and CAVI. With correlation coefficient between r = 0.450 (cfPWV and diastolic blood pressure) and r = 0.128 (between CAVI and triglycerides). After adjustment for age and sex the correlation remains the same with the cfPWV. However, it is only maintained with the CAVI only with blood pressure. Subjects with MetS have odds ratio (OR) for both cfPWV ≥ 10 m/sec (OR = 1.884, 95 % CI 0.996–3.486) and CAVI ≥ 9 (OR = 1.810, 95 % CI 0.749–4.372). Conclusions: The cfPWV showed the positive correlation, after adjusting it for age and sex with all the components of the MetS, however the CAVI showed the positive correlation with the arterial pressure.