Neurobiology of Disease (Oct 2002)
A Twin Study of Genetic Contributions to Hippocampal Morphology in Schizophrenia
- Katherine L. Narr,
- Theo G.M. van Erp,
- Tyrone D. Cannon,
- Roger P. Woods,
- Paul M. Thompson,
- Seonah Jang,
- Rebecca Blanton,
- Veli-Pekka Poutanen,
- Matti Huttunen,
- Jouko Lönnqvist,
- Carl-Gustav Standerksjöld-Nordenstam,
- Jaakko Kaprio,
- John C. Mazziotta,
- Arthur W. Toga
Affiliations
- Katherine L. Narr
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Theo G.M. van Erp
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Tyrone D. Cannon
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Roger P. Woods
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Paul M. Thompson
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Seonah Jang
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Rebecca Blanton
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Veli-Pekka Poutanen
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Matti Huttunen
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Jouko Lönnqvist
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Carl-Gustav Standerksjöld-Nordenstam
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Jaakko Kaprio
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- John C. Mazziotta
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Arthur W. Toga
- Laboratory of Neuro Imaging, Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Departments of Psychology, Psychiatry, Human Genetics, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Neurology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Brain Mapping Center, Department of Neurology, Psychiatry, Human Genetics, Department of Radiology and Pharmacology, UCLA Brain Mapping Center, Ahmanson–Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, California, 90095; Department of Radiology, Helsinki University Central Hospital, Meilahti Clinics, Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki, Finland; Department of Public Health, Universities of Helsinki and Oulu, Finland
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 83 – 95
Abstract
Our goal was to establish whether altered hippocampal morphology represents a trait marker for genetic vulnerability in schizophrenia. We outlined the hippocampi on high-resolution MR images obtained from matched samples of control and discordant monozygotic and dizygotic co-twins (N = 40 pairs). Hippocampal measures were used in statistical tests specifically designed to identify disease-associated genetic and nongenetic influences on morphology. 3D surface average maps of the hippocampus were additionally compared in biological risk groups. Smaller hippocampal volumes were confirmed in schizophrenia. Dizygotic affected co-twins showed smaller left hippocampi compared to their healthy siblings. Disease-associated effects were not present between monozygotic discordant co-twins. Monozygotic, but not dizygotic, unaffected co-twins exhibited smaller left hippocampi compared to control twins, supporting genetic influences. Surface areas and posterior volumes similarly revealed schizophrenia and genetic liability effects. Results suggest that hippocampal volume reduction may be a trait marker for identifying individuals possessing a genetic predisposition for schizophrenia.
