Frontiers in Astronomy and Space Sciences (Jul 2021)
Towards a Biomanufactory on Mars
- Aaron J. Berliner,
- Aaron J. Berliner,
- Jacob M. Hilzinger,
- Jacob M. Hilzinger,
- Anthony J. Abel,
- Anthony J. Abel,
- Matthew J. McNulty,
- Matthew J. McNulty,
- George Makrygiorgos,
- George Makrygiorgos,
- Nils J. H. Averesch,
- Nils J. H. Averesch,
- Soumyajit Sen Gupta,
- Soumyajit Sen Gupta,
- Alexander Benvenuti,
- Alexander Benvenuti,
- Daniel F. Caddell,
- Daniel F. Caddell,
- Stefano Cestellos-Blanco,
- Stefano Cestellos-Blanco,
- Anna Doloman,
- Anna Doloman,
- Skyler Friedline,
- Skyler Friedline,
- Davian Ho,
- Davian Ho,
- Wenyu Gu,
- Wenyu Gu,
- Avery Hill,
- Avery Hill,
- Paul Kusuma,
- Paul Kusuma,
- Isaac Lipsky,
- Isaac Lipsky,
- Mia Mirkovic,
- Mia Mirkovic,
- Jorge Luis Meraz,
- Jorge Luis Meraz,
- Vincent Pane,
- Vincent Pane,
- Kyle B. Sander,
- Kyle B. Sander,
- Fengzhe Shi,
- Fengzhe Shi,
- Jeffrey M. Skerker,
- Jeffrey M. Skerker,
- Alexander Styer,
- Alexander Styer,
- Kyle Valgardson,
- Kyle Valgardson,
- Kelly Wetmore,
- Kelly Wetmore,
- Sung-Geun Woo,
- Sung-Geun Woo,
- Yongao Xiong,
- Yongao Xiong,
- Kevin Yates,
- Kevin Yates,
- Cindy Zhang,
- Cindy Zhang,
- Shuyang Zhen,
- Shuyang Zhen,
- Bruce Bugbee,
- Bruce Bugbee,
- Douglas S. Clark,
- Douglas S. Clark,
- Douglas S. Clark,
- Devin Coleman-Derr,
- Devin Coleman-Derr,
- Ali Mesbah,
- Ali Mesbah,
- Somen Nandi,
- Somen Nandi,
- Somen Nandi,
- Robert M. Waymouth,
- Robert M. Waymouth,
- Peidong Yang,
- Peidong Yang,
- Peidong Yang,
- Peidong Yang,
- Craig S. Criddle,
- Craig S. Criddle,
- Karen A. McDonald,
- Karen A. McDonald,
- Karen A. McDonald,
- Lance C. Seefeldt,
- Lance C. Seefeldt,
- Amor A. Menezes,
- Amor A. Menezes,
- Adam P. Arkin,
- Adam P. Arkin,
- Adam P. Arkin
Affiliations
- Aaron J. Berliner
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Aaron J. Berliner
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Jacob M. Hilzinger
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Jacob M. Hilzinger
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Anthony J. Abel
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Anthony J. Abel
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Matthew J. McNulty
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Matthew J. McNulty
- Department of Chemical Engineering, University of California Davis, Davis, CA, United States
- George Makrygiorgos
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- George Makrygiorgos
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Nils J. H. Averesch
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Nils J. H. Averesch
- Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, United States
- Soumyajit Sen Gupta
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Soumyajit Sen Gupta
- Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United States
- Alexander Benvenuti
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Alexander Benvenuti
- Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United States
- Daniel F. Caddell
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Daniel F. Caddell
- Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, United States
- Stefano Cestellos-Blanco
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Stefano Cestellos-Blanco
- Department of Materials Science and Engineering, University of California Berkeley, Berkeley, CA, United States
- Anna Doloman
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Anna Doloman
- Department of Chemistry and Biochemistry, Utah State University, Logan, UT, United States
- Skyler Friedline
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Skyler Friedline
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Davian Ho
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Davian Ho
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Wenyu Gu
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Wenyu Gu
- Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, United States
- Avery Hill
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Avery Hill
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Paul Kusuma
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Paul Kusuma
- 0Department of Plants, Soils, and Climate, Utah State University, Logan, UT, United States
- Isaac Lipsky
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Isaac Lipsky
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Mia Mirkovic
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Mia Mirkovic
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Jorge Luis Meraz
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Jorge Luis Meraz
- Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, United States
- Vincent Pane
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Vincent Pane
- 1Department of Chemistry, Stanford University, Stanford, CA, United States
- Kyle B. Sander
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Kyle B. Sander
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Fengzhe Shi
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Fengzhe Shi
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Jeffrey M. Skerker
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Jeffrey M. Skerker
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Alexander Styer
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Alexander Styer
- Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, United States
- Kyle Valgardson
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Kyle Valgardson
- Department of Chemistry and Biochemistry, Utah State University, Logan, UT, United States
- Kelly Wetmore
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Kelly Wetmore
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Sung-Geun Woo
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Sung-Geun Woo
- Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, United States
- Yongao Xiong
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Yongao Xiong
- Department of Chemical Engineering, University of California Davis, Davis, CA, United States
- Kevin Yates
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Kevin Yates
- Department of Chemical Engineering, University of California Davis, Davis, CA, United States
- Cindy Zhang
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Cindy Zhang
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Shuyang Zhen
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Shuyang Zhen
- 2Department of Horticultural Sciences, Texas A&M University, College Station, TX, United States
- Bruce Bugbee
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Bruce Bugbee
- 0Department of Plants, Soils, and Climate, Utah State University, Logan, UT, United States
- Douglas S. Clark
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Douglas S. Clark
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Douglas S. Clark
- 3Lawrence Berkeley National Laboratory, Berkeley, CA, United States
- Devin Coleman-Derr
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Devin Coleman-Derr
- Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, United States
- Ali Mesbah
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Ali Mesbah
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Somen Nandi
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Somen Nandi
- Department of Chemical Engineering, University of California Davis, Davis, CA, United States
- Somen Nandi
- 4Global HealthShare Initiative, Davis, CA, United States
- Robert M. Waymouth
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Robert M. Waymouth
- 1Department of Chemistry, Stanford University, Stanford, CA, United States
- Peidong Yang
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Peidong Yang
- Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, United States
- Peidong Yang
- Department of Materials Science and Engineering, University of California Berkeley, Berkeley, CA, United States
- Peidong Yang
- 5Kavli Energy Nanosciences Institute, Berkeley, CA, United States
- Craig S. Criddle
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Craig S. Criddle
- Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, United States
- Karen A. McDonald
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Karen A. McDonald
- Department of Chemical Engineering, University of California Davis, Davis, CA, United States
- Karen A. McDonald
- 4Global HealthShare Initiative, Davis, CA, United States
- Lance C. Seefeldt
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Lance C. Seefeldt
- Department of Chemistry and Biochemistry, Utah State University, Logan, UT, United States
- Amor A. Menezes
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Amor A. Menezes
- Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United States
- Adam P. Arkin
- Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, United States
- Adam P. Arkin
- Department of Bioengineering, University of California Berkeley, Berkeley, CA, United States
- Adam P. Arkin
- 3Lawrence Berkeley National Laboratory, Berkeley, CA, United States
- DOI
- https://doi.org/10.3389/fspas.2021.711550
- Journal volume & issue
-
Vol. 8
Abstract
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific and engineering goals and constraints, along with example systems, that guide the design of a surface biomanufactory. Extending past arguments for exploiting stand-alone elements of biology, we argue for an integrated biomanufacturing plant replete with modules for microbial in situ resource utilization, production, and recycling of food, pharmaceuticals, and biomaterials required for sustaining future intrepid astronauts. We also discuss aspirational technology trends in each of these target areas in the context of human and robotic exploration missions.
Keywords
- space systems bioengineering
- human exploration
- in situ resource utilization
- life support systems
- biomanufacturing
