Cellular landscaping of cisplatin resistance in cervical cancer

Rahul Bhattacharjee; Tanima Dey; Lamha Kumar; Sulagna Kar; Ritayan Sarkar; Mimosa Ghorai; Sumira Malik; Niraj Kumar Jha; Balachandar Vellingiri; Kavindra Kumar Kesari; José M. Pérez de la Lastra; Abhijit Dey

Biomedicine & Pharmacotherapy (Sep 2022)

Cellular landscaping of cisplatin resistance in cervical cancer

Rahul Bhattacharjee,
Tanima Dey,
Lamha Kumar,
Sulagna Kar,
Ritayan Sarkar,
Mimosa Ghorai,
Sumira Malik,
Niraj Kumar Jha,
Balachandar Vellingiri,
Kavindra Kumar Kesari,
José M. Pérez de la Lastra,
Abhijit Dey

Affiliations

Rahul Bhattacharjee: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar 751024, Odisha, India
Tanima Dey: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar 751024, Odisha, India
Lamha Kumar: School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram 695551, Kerala, India
Sulagna Kar: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar 751024, Odisha, India
Ritayan Sarkar: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar 751024, Odisha, India
Mimosa Ghorai: Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India
Sumira Malik: Amity Institute of Biotechnology, Amity University Jharkhand, Ranchi, Jharkhand 834001, India
Niraj Kumar Jha: Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India; Corresponding author at: Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India.
Balachandar Vellingiri: Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641–046, India
Kavindra Kumar Kesari: Department of Applied Physics, School of Science, Aalto University, Espoo 00076, Finland; Department of Bio-products and Bio-systems, School of Chemical Engineering, Aalto University, Espoo 00076, Finland
José M. Pérez de la Lastra: Biotechnology of Macromolecules, Instituto de Productos Naturales y Agrobiología, IPNA (CSIC), Avda. Astrofísico Francisco Sánchez, 3, 38206 San Cristóbal de la Laguna (Santa Cruz de Tenerife), Spain; Corresponding authors.
Abhijit Dey: Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India; Corresponding authors.

Journal volume & issue: Vol. 153
p. 113345

Abstract

Read online

Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

About the journal

Abstract

Keywords