Nature Communications (Oct 2018)

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel

  • Marieke W. Veldkamp,
  • Guillaume S. C. Geuzebroek,
  • Antonius Baartscheer,
  • Arie O. Verkerk,
  • Cees A. Schumacher,
  • Gedeon G. Suarez,
  • Wouter R. Berger,
  • Simona Casini,
  • Shirley C. M. van Amersfoorth,
  • Koen T. Scholman,
  • Antoine H. G. Driessen,
  • Charly N. W. Belterman,
  • Antoni C. G. van Ginneken,
  • Joris R. de Groot,
  • Jacques M. T. de Bakker,
  • Carol Ann Remme,
  • Bas J. Boukens,
  • Ruben Coronel

DOI
https://doi.org/10.1038/s41467-018-06530-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.