Nature Communications (Apr 2018)

A nanofluidic knot factory based on compression of single DNA in nanochannels

  • Susan Amin,
  • Ahmed Khorshid,
  • Lili Zeng,
  • Philip Zimny,
  • Walter Reisner

DOI
https://doi.org/10.1038/s41467-018-03901-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Polymer knots are important for a range of biological systems and engineering applications, yet the variables influencing knotting probability are not well understood. Here the authors develop a nanofluidic device that can detect knots and provide a free energy formalism that can quantify knotting probability in their system.