Bangladesh Journal of Pharmacology (Sep 2015)

Anti-oxidant and hepatoprotective activities of total flavonoids of Indocalamus latifolius

  • Juan Tan,
  • Li Shenghua,
  • Junying Zeng,
  • Xianjin Wu

DOI
https://doi.org/10.3329/bjp.v10i4.23496
Journal volume & issue
Vol. 10, no. 4

Abstract

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The total flavonoids of Indocalamus latifolius were evaluated in term of their anti-oxidant and hepatoprotective activities. The results showed that in vitrohepatoprotective and anti-oxidant activities of total flavonoids at doses of 200 and 400 mg/kg and 100 mg/kg, respectively, were comparable to those of the known hepatoprotective drug silymarin at 100 mg/kg. These data were supplemented with histopathological studies of rat liver sections. Seven of the main flavonoid compounds purified by column chromatography using silica gel, sephadex LH-20 and develosil ODS, and determined to be vitexin, orientin, isovitexin, homoorientin, tricin, tricin-7-O-β-D-glucopyranoside and quercetin-3-O-glucopyranoside.

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