Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

Jiandong Yang; Yoshikazu Hirai; Kei Iida; Shinji Ito; Marika Trumm; Shiho Terada; Risako Sakai; Toshiyuki Tsuchiya; Osamu Tabata; Ken-ichiro Kamei

doi:10.1038/s42003-023-04710-8

Communications Biology (Mar 2023)

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

Jiandong Yang,
Yoshikazu Hirai,
Kei Iida,
Shinji Ito,
Marika Trumm,
Shiho Terada,
Risako Sakai,
Toshiyuki Tsuchiya,
Osamu Tabata,
Ken-ichiro Kamei

Affiliations

Jiandong Yang: Department of Micro Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo-ku
Yoshikazu Hirai: Department of Micro Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo-ku
Kei Iida: Medical Research Support Center, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho
Shinji Ito: Faculty of Science and Engineering, Kindai University, 3-4-1 Kowakae, Higashiosaka
Marika Trumm: Department of Micro Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo-ku
Shiho Terada: Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku
Risako Sakai: Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku
Toshiyuki Tsuchiya: Department of Micro Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo-ku
Osamu Tabata: Department of Micro Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo-ku
Ken-ichiro Kamei: Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku

DOI: https://doi.org/10.1038/s42003-023-04710-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

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A model system for studying non-alcoholic fatty liver disease is created by co-culturing human gut and liver cell lines in a closed circulation loop using microfluidics.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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