Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

Shoko Ito; Satoru Okuda; Masako Abe; Mari Fujimoto; Tetsuo Onuki; Tamako Nishimura; Masatoshi Takeichi

doi:10.1038/s41467-017-01945-y

Nature Communications (Nov 2017)

Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

Shoko Ito,
Satoru Okuda,
Masako Abe,
Mari Fujimoto,
Tetsuo Onuki,
Tamako Nishimura,
Masatoshi Takeichi

Affiliations

Shoko Ito: Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku
Satoru Okuda: Laboratoty for In Vitro Histogenesis, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku
Masako Abe: Seed Compounds Exploratory Unit for Drug Discovery Platform, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa
Mari Fujimoto: Seed Compounds Exploratory Unit for Drug Discovery Platform, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa
Tetsuo Onuki: Seed Compounds Exploratory Unit for Drug Discovery Platform, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa
Tamako Nishimura: Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku
Masatoshi Takeichi: Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku

DOI: https://doi.org/10.1038/s41467-017-01945-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

Cancer cells can disrupt cell-to-cell junctions, thus allowing migration and metastasis. Here starting from a chemical screening, Ito et al. reconstitute a step-by-step mechanism linking microtubule depolymerization and epithelial cell junction restoration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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