Nature Communications (Nov 2017)
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
- Benoit Bilanges,
- Samira Alliouachene,
- Wayne Pearce,
- Daniele Morelli,
- Gyorgy Szabadkai,
- Yuen-Li Chung,
- Gaëtan Chicanne,
- Colin Valet,
- Julia M. Hill,
- Peter J. Voshol,
- Lucy Collinson,
- Christopher Peddie,
- Khaled Ali,
- Essam Ghazaly,
- Vinothini Rajeeve,
- Georgios Trichas,
- Shankar Srinivas,
- Claire Chaussade,
- Rachel S. Salamon,
- Jonathan M. Backer,
- Cheryl L. Scudamore,
- Maria A. Whitehead,
- Erin P. Keaney,
- Leon O. Murphy,
- Robert K. Semple,
- Bernard Payrastre,
- Sharon A. Tooze,
- Bart Vanhaesebroeck
Affiliations
- Benoit Bilanges
- UCL Cancer Institute, University College London
- Samira Alliouachene
- UCL Cancer Institute, University College London
- Wayne Pearce
- UCL Cancer Institute, University College London
- Daniele Morelli
- UCL Cancer Institute, University College London
- Gyorgy Szabadkai
- Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London
- Yuen-Li Chung
- Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research London
- Gaëtan Chicanne
- Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires
- Colin Valet
- Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires
- Julia M. Hill
- Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London
- Peter J. Voshol
- Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science
- Lucy Collinson
- The Francis Crick Institute, Lincoln’s Inn Fields Laboratories
- Christopher Peddie
- The Francis Crick Institute, Lincoln’s Inn Fields Laboratories
- Khaled Ali
- UCL Cancer Institute, University College London
- Essam Ghazaly
- Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London
- Vinothini Rajeeve
- Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London
- Georgios Trichas
- Department of Physiology Anatomy and Genetics, University of Oxford
- Shankar Srinivas
- Department of Physiology Anatomy and Genetics, University of Oxford
- Claire Chaussade
- UCL Cancer Institute, University College London
- Rachel S. Salamon
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Jonathan M. Backer
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Cheryl L. Scudamore
- Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus
- Maria A. Whitehead
- UCL Cancer Institute, University College London
- Erin P. Keaney
- Novartis Institutes for BioMedical Research
- Leon O. Murphy
- Novartis Institutes for BioMedical Research
- Robert K. Semple
- Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
- Bernard Payrastre
- Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires
- Sharon A. Tooze
- The Francis Crick Institute, Lincoln’s Inn Fields Laboratories
- Bart Vanhaesebroeck
- UCL Cancer Institute, University College London
- DOI
- https://doi.org/10.1038/s41467-017-01969-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism.
