Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

Abstract

A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.

Keywords

• cADPR analogue
• acyclic cADPR analogue
• trifluoromethylation
• synthesis