MICROECOLOGICAL CHARACTERISTICS OF KLEBSIELLA SPP. REGIONAL POPULATIONS IN THE INTESTINAL MICROBIOTA OF IRKUTSK CHILDREN

Abstract

In this paper the microecological characteristics of Klebsiella spp. regional populations in the intestinal microbiota of infants were represented. 373 children (55,9 % of general quantity of researched) had disbiotic changes of intestinal microbiota related to increasing number of Klebsiella. The autostrains sensitivity to antibiotic drugs (в-lactams, aminoglycosides, quinolones) and to purified Klebsiella pneumoniae phage and purified polyvalent Klebsiella phage were researched. Samples of isolates (n = 142) characterized by a high proportion of antibiotic susceptible strains. Phage sensitivity of bacteriophage to the commercial preparations was determined in 268 strains of Klebsiella spp. of two types (146 strains of K. Oxytoca and 122 strains of K. pneumonia). Probably high frequency of pathogens resistant to studied bacteriophages (K. oxytocain 66 % and K. pneumoniae in 77.8 % of cases) was the reason of low efficiency of phage therapy by specific phage and can explain high frequency of occurrence of Klebsiella at dysbiosis in children of early age.

Keywords

• intestinal microbiota
• disbiotic disorder
• antibiotic susceptibility
• phagosensitivity