Nature Communications (Jun 2019)
Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
- Kim R. Kampen,
- Laura Fancello,
- Tiziana Girardi,
- Gianmarco Rinaldi,
- Mélanie Planque,
- Sergey O. Sulima,
- Fabricio Loayza-Puch,
- Benno Verbelen,
- Stijn Vereecke,
- Jelle Verbeeck,
- Joyce Op de Beeck,
- Jonathan Royaert,
- Pieter Vermeersch,
- David Cassiman,
- Jan Cools,
- Reuven Agami,
- Mark Fiers,
- Sarah-Maria Fendt,
- Kim De Keersmaecker
Affiliations
- Kim R. Kampen
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Laura Fancello
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Tiziana Girardi
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Gianmarco Rinaldi
- Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology
- Mélanie Planque
- Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology
- Sergey O. Sulima
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Fabricio Loayza-Puch
- Translational Control and Metabolism, German Cancer Research Center (DKFZ)
- Benno Verbelen
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Stijn Vereecke
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Jelle Verbeeck
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Joyce Op de Beeck
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Jonathan Royaert
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- Pieter Vermeersch
- Department of Laboratory Medicine, University Hospitals Leuven
- David Cassiman
- Department of Gastroenterology-Hepatology and Metabolic Center, University Hospitals Leuven
- Jan Cools
- Laboratory of Molecular Biology of Leukemia, VIB-KU Leuven Center for Cancer Biology
- Reuven Agami
- Department of Pediatric Oncology/Hematology, Erasmus Medical Center
- Mark Fiers
- Laboratory for the Research of Neurodegenerative Diseases, VIB-KU Leuven Center for Brain & Disease Research
- Sarah-Maria Fendt
- Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology
- Kim De Keersmaecker
- Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)
- DOI
- https://doi.org/10.1038/s41467-019-10508-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.
