Turkish Journal of Hematology (Aug 2022)

Preliminary Report of the Academic CAR-T (ISIKOK-19) Cell Clinical Trial in Turkey: Characterization of Product and Outcomes of Clinical Application

  • Ebru Erdoğan,
  • Koray Yalçın,
  • Cansu Hemşinlioğlu,
  • Aslıhan Sezgin,
  • Utku Seyis,
  • Derya Dilek Kancağı,
  • Cihan Taştan,
  • Bulut Yurtsever,
  • Raife Dilek Turan,
  • Didem Çakırsoy,
  • Selen Abanuz,
  • Gözde Sır Karakuş,
  • Muhammer Elek,
  • Hüseyin Saffet Beköz,
  • Ali İhsan Gemici,
  • Deniz Sargın,
  • Mutlu Arat,
  • Burhan Ferhanoğlu,
  • Ebru Pekgüç,
  • Serdar Örnek,
  • Deram Büyüktaş,
  • Nur Birgen,
  • Siret Ratip,
  • Ercüment Ovalı

DOI
https://doi.org/10.4274/tjh.galenos.2022.2022.0193
Journal volume & issue
Vol. 39, no. 3
pp. 206 – 210

Abstract

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Objective: Chimeric antigen receptor T (CAR-T) cell therapies have already made an impact on the treatment of B-cell malignancies. Although CAR-T cell therapies are promising, there are concerns about commercial products regarding their affordability and sustainability. In this preliminary study, the results of the first production and clinical data of an academic CAR-T cell (ISIKOK-19) trial in Turkey are presented. Materials and Methods: A pilot clinical trial (NCT04206943) designed to assess the safety and feasibility of ISIKOK-19 T-cell therapy for patients with relapsed and refractory CD19+ tumors was conducted and participating patients received ISIKOK-19 infusions between October 2019 and July 2021. The production data of the first 8 patients and the clinical outcome of 7 patients who received ISIKOK-19 cell infusions are presented in this study. Results: Nine patients were enrolled in the trial [5 with acute lymphoblastic leukemia (ALL) and 4 with non-Hodgkin lymphoma (NHL)], but only 7 patients could receive treatment. Two of the 3 participating ALL patients and 3 of the 4 NHL patients had complete/ partial response (overall response rate: 72%). Four patients (57%) had CAR-T-related toxicities (cytokine release syndrome, CAR-T-related encephalopathy syndrome, and pancytopenia). Two patients were unresponsive and had progressive disease following CAR-T therapy. Two patients with partial response had progressive disease during follow-up. Conclusion: Production efficacy and fulfillment of the criteria of quality control were satisfactory for academic production. Response rates and toxicity profiles were also acceptable for this heavily pretreated/refractory patient group. ISIKOK-19 cells appear to be a safe, economical, and efficient treatment option for CD19+ tumors. However, the findings of this study need to be supported by the currently ongoing ISIKOK-19 clinical trial.

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