Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins

Emma R. Hinkle; R. Eric Blue; Yi-Hsuan Tsai; Matthew Combs; Jacquelyn Davi; Alisha R. Coffey; Aladin M. Boriek; Joan M. Taylor; Joel S. Parker; Jimena Giudice

doi:10.1038/s42003-022-03915-7

Communications Biology (Sep 2022)

Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins

Emma R. Hinkle,
R. Eric Blue,
Yi-Hsuan Tsai,
Matthew Combs,
Jacquelyn Davi,
Alisha R. Coffey,
Aladin M. Boriek,
Joan M. Taylor,
Joel S. Parker,
Jimena Giudice

Affiliations

Emma R. Hinkle: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill
R. Eric Blue: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill
Yi-Hsuan Tsai: Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
Matthew Combs: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Jacquelyn Davi: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill
Alisha R. Coffey: Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
Aladin M. Boriek: Department of Medicine, Baylor College of Medicine
Joan M. Taylor: Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill
Joel S. Parker: Curriculum in Genetics and Molecular Biology (GMB), The University of North Carolina at Chapel Hill
Jimena Giudice: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s42003-022-03915-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Mechanical stretching of skeletal muscle cells induces extensive transcriptional and posttranscriptional changes in genes encoding proteins involved in transcription and muscle cell differentiation. SR proteins also exhibit altered transcription and phosphorylation in response to stretch.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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