Nature Communications (Oct 2018)

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

  • Alexander Benjamin Schendzielorz,
  • Piotr Bragoszewski,
  • Nataliia Naumenko,
  • Ridhima Gomkale,
  • Christian Schulz,
  • Bernard Guiard,
  • Agnieszka Chacinska,
  • Peter Rehling

DOI
https://doi.org/10.1038/s41467-018-06492-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.