Development and Evaluation of <i>Ginkgo biloba</i> L. Extract Loaded into Carboxymethyl Cellulose Sublingual Films

Abstract

Oral bioavailability of flavonoids, including G. biloba extract, is limited due to their chemical complexity, which determines slow dissolution in vitro behavior of the extract. The overall research objective was to compare the effect of increasing freeze-dried G. biloba extract (GFD) concentrations in carboxymethyl cellulose (CMC) films on their mechanical properties, release profile of flavonoid glycosides, stability and disintegration time. Physicochemical evaluation of films was performed by SEM and FTIR. The mechanical properties and in vitro release profile of flavonoid glycosides from the prepared films were characterized in the study. The higher elongation at break and tensile strength values, quick release of flavonoids and good stability were observed in formulation, coded FRG—15 (the film contained 0.4 g of GFD, 0.3 g of glycerol and 2 g of 2% CMC), (p G. biloba extract-based dosage forms, which might increase the multifunctional properties and pharmacological activity closer to the desired level.

Keywords

• <i>Gingko biloba</i> L. freeze-dried extract
• dissolution rate of flavonoids
• mucoadhesive drug delivery system