The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Sara Valpione; Piyushkumar A. Mundra; Elena Galvani; Luca G. Campana; Paul Lorigan; Francesco De Rosa; Avinash Gupta; John Weightman; Sarah Mills; Nathalie Dhomen; Richard Marais

doi:10.1038/s41467-021-24343-x

Nature Communications (Jul 2021)

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Sara Valpione,
Piyushkumar A. Mundra,
Elena Galvani,
Luca G. Campana,
Paul Lorigan,
Francesco De Rosa,
Avinash Gupta,
John Weightman,
Sarah Mills,
Nathalie Dhomen,
Richard Marais

Affiliations

Sara Valpione: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Piyushkumar A. Mundra: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Elena Galvani: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Luca G. Campana: Medical Oncology, The Christie NHS Foundation Trust
Paul Lorigan: Medical Oncology, The Christie NHS Foundation Trust
Francesco De Rosa: Immunotherapy - Cell Therapy and Biobank, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori” IRCCS
Avinash Gupta: Medical Oncology, The Christie NHS Foundation Trust
John Weightman: Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester
Sarah Mills: Manchester Cancer Research Centre Biobank, The Christie NHS Foundation Trust
Nathalie Dhomen: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Richard Marais: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/s41467-021-24343-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Precision medicine needs prognostic markers to select the patients that will benefit more from targeted therapy. Authors show here that high level of baseline T cell receptor diversity is an indicator of favourable prognosis in multiple cancer types, and monoclonal expansion of T-cells correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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