Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test

Aleksandra Leligdowicz; Andrea L. Conroy; Michael Hawkes; Melissa Richard-Greenblatt; Kathleen Zhong; Robert O. Opoka; Sophie Namasopo; David Bell; W. Conrad Liles; Bruno R. da Costa; Peter Jüni; Kevin C. Kain

doi:10.1038/s41467-021-27215-6

Nature Communications (Nov 2021)

Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test

Aleksandra Leligdowicz,
Andrea L. Conroy,
Michael Hawkes,
Melissa Richard-Greenblatt,
Kathleen Zhong,
Robert O. Opoka,
Sophie Namasopo,
David Bell,
W. Conrad Liles,
Bruno R. da Costa,
Peter Jüni,
Kevin C. Kain

Affiliations

Aleksandra Leligdowicz: Robarts Research Institute, University of Western Ontario
Andrea L. Conroy: Department of Pediatrics, Indiana University School of Medicine
Michael Hawkes: Division of Pediatric Infectious Diseases, 3-593 Edmonton Clinic Health Academy, University of Alberta
Melissa Richard-Greenblatt: Toronto General Hospital, University Health Network, Sandra Rotman Centre for Global Health, MaRS Centre
Kathleen Zhong: Toronto General Hospital, University Health Network, Sandra Rotman Centre for Global Health, MaRS Centre
Robert O. Opoka: Department of Paediatrics and Child Health, Mulago Hospital and Makerere University
Sophie Namasopo: Department of Pediatrics, Kabale District Hospital
David Bell: Independent consultant
W. Conrad Liles: Departments of Medicine, Pathology, Global Health, and Pharmacology, 1959 NE Pacific Street; HSB RR-511, Box 356420, University of Washington
Bruno R. da Costa: Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael’s Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto
Peter Jüni: Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael’s Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto
Kevin C. Kain: Tropical Disease Unit, Sandra Rotman Centre for Global Health, Toronto General Hospital, University Health Network, Department of Medicine, University of Toronto, MaRS Centre

DOI: https://doi.org/10.1038/s41467-021-27215-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

Identification of febrile children at risk of death in low-resource settings can improve survival, but tools for their prompt recognition are lacking. Here, the authors show that sTREM-1 measured at clinical presentation predicts in-hospital mortality in febrile children in Uganda.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal