Antiaggregant impact of vascular wall on hemocyte in hypertension patients with dyslipidemia taking simvastatin

Abstract

The work purpose — to define at patients with an arterial hypertension with a dyslipidemia extent of influence simvastatin on antiaggregatory control from vessels over erythrocytes, platelets and leukocytes. The arterial hypertension registered at patients with a dyslipidemia the strengthened aggregation of erythrocytes, platelets and neutrophils develops against decrease in control over it from the vascular wall, arising in many respects at the expense of violations in a lipidic exchange, activation of oxidation of lipids of plasma and weakening of generation of oxide of nitrogen and education prostacyclin. As a result of 104 week applications simvastatin at patients with an arterial hypertension with a dyslipidemia normalization of lipidic structure, processes of lipid peroxidation in plasma and blood cells and antiaggregatory ability of a vascular wall is reached.

Keywords

• артериальная гипертония
• дислипидемия
• симвастатин
• антиагрегационная активность сосудистой стенки
• эритроциты
• тромбоциты
• нейтрофилы